The aging process is more than just the passage of years. Indeed, each of those passing years is merely the timeline on which the progressive decline of physiological functions such as kidney failure or cardiovascular issues. Like all moving parts, whether in the human body or a mechanical device, time degrades performance. Recent studies have suggested, however, that the anti-aging protein Klotho has putative effects on those suffering from renal failure and cardiovascular disease.
A Novel Protein Linked to the Aging Process
A gene known for encoding a new protein that is responsible for regulating numerous functions that have been identified as serving to extend the life function as it relates to patients suffering from renal failure or cardiovascular diseases. Recent studies note that when researchers look at mice, the lack of a Klothos gene can be the cause of phenotype of the premature aging process that presents as vascular calcification resulting in a shortened lifespan.
Links Between Klothos and Renal Failure
The Klothos protein is found in one of two forms. The first, or Type I, offers a large extracellular domain with a short portion that is primarily expressed in the renal tubules that have a circulating soluble factor that is detectable in blood. Soluble Klothos, or S-Klothos, appear to have a direct link between chronic kidney diseases. The combination of the Klothos genes and other factors have yet to be fully explored to better understand the link between the life shortening conditions such as renal failure or cardiovascular issues. Mice populations deficient in Klothos are more prone to life-threatening chronic conditions.
Final Thoughts on Soluble Klothos
Evidence has emerged that draws a direct line between Klotho in calcium-phosphate metabolism and caring for the body’s vascular health. As such, scientists are intrigued by the possibility that Klotho might well be thought of as a useful biomarker to better identify and analysis of future cardiovascular and renal diseases. Looking forward, more study is needed to better understand the linkage between these life-extending proteins and the identification and treatment of chronic health conditions that plague mankind.